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RESEARCH

Unveiling Breakthroughs in Neuroscience

Vital Tones develops Deep Brain Sound Stimulation (DBSS), a non-invasive auditory neuromodulation technology designed to interact with specific brain and body systems through precisely structured sound. Developed over more than twelve years, DBSS has been applied across neurological, psychological, cognitive, and physical conditions, with research ranging from large-scale observational studies to MRI-documented case reports.

 

Below is an overview of published, preprint, and ongoing DBSS research covering neurological, psychological, cognitive, and physical applications.

 

Published and Preprint Research

Our research portfolio includes both peer-reviewed publications and preprints available for public access. The research portfolio includes peer-reviewed publications, preprints, case reports, and ongoing studies available for public examination. Together, they document the developing scope of DBSS across different neurological, psychological, and physical applications. Click on any study title to access the full report.

 

Peer-Reviewed Publication:

 

 

Preprints (Under Review for Publication):

 

Joint and Ligament Regeneration Using DBSS

 

  • Audio Brainwave Treatment Restores Chronic ACL–PCL Ruptures: MRI-Verified Case Report
    This MRI-verified case highlights a promising direction for DBSS in chronic physical injury. A patient with long-standing ACL–PCL ruptures showed structural improvement following a Vital Tones sound-based stimulation protocol, documented by pre- and post-treatment MRI. The findings support further investigation of DBSS in ligament and joint regeneration.
    • Evidence: Pre- and post-MRI scans showing improvement
    • Safety: No side effects reported

       We are now collecting more MRI cases to prepare a larger, multi-patient clinical report.

       If you're interested in contributing to this study, please refer to the full report for participation information.

 

 

Spinal Disc Regeneration Using DBSS

 

    • Evidence: Pre- and post-MRI reports showing resolution
    • Safety: No side effects reported

       If researchers are interested in conducting replication studies, they are welcome to contact us..

 

 

Core DBSS Technology and Overview

 

    • Study Scope: Over 6,400 users across 50 therapy applications
    • User Satisfaction: 98.5%
    • Safety: Minimal adverse effects
    • Reported Benefits: Cognitive, emotional, and motor improvements across conditions such as anxiety, depression, ADHD, Parkinson’s disease, and PTSD

 

Neurological and Psychological Disorders

 

    • Reported Improvement: 50% improvement in mood regulation
    • User Satisfaction: 99.59%

 

    • Reported Improvement: 65% improvement in mood stability
    • User Satisfaction: 97.78%

 

    • Reported Improvement: 65% reduction in anxiety symptoms
    • User Satisfaction: 99.03%

 

    • Reported Improvement: 50% improvement reported for DTD, and 80% for PTSD in symptom reduction
    • User Satisfaction: 97.50% for DTD, 99.47% for PTSD

 

    • Reported Improvement: 57% improvement in ADHD symptoms, including attention and hyperactivity
    • User Satisfaction: 99.77%

 

    • Reported Improvement: 65% improvement in phonological awareness and reading fluency
    • User Satisfaction: 100%

 

    • Reported Improvement: 80% for Insomnia, 65% for Deep Sleep
    • User Satisfaction: 99.30% (Insomnia), 99.53% (Deep Sleep)

 

    • Reported Improvement:50% reduction in OCD symptoms
    • User Satisfaction: 99.12%

 

    • Reported Improvement: 50% improvement in emotional regulation and impulsivity
    • User Satisfaction: 99.26%

 

 

Menstrual Pain Relief Using DBSS (Public Study in Progress):

A publicly available sound-based session is currently being evaluated for its use during menstrual pain.

The session is hosted here.

It is designed to support relaxation and comfort during menstruation. Participation is voluntary, and the session is freely accessible.

Participants are invited to share anonymous feedback after each menstrual period has finished. This helps assess experiences across the cycle and supports ongoing research insights.

Feedback Form

 

 

Stuttering Fluency Improvement (Public Study in Progress)

A single 5-minute sound-based session is now being evaluated for speech fluency improvement in individuals who stutter. Early testers have reported noticeably smoother speech and higher confidence after listening once. We are inviting additional participants to help gather further data. The session is included within the form for direct listening and response.

 

Feedback Form

 

 

Severe Knee Degeneration (Ongoing Single-Case Observation):

This case involves advanced knee degeneration, including cartilage erosion, ligament weakening, bone deformity, and synovial fluid loss. Prior to treatment, the participant experienced severe chronic pain and was advised to undergo partial knee prosthesis surgery. Joint-fluid injections provided only temporary relief. During therapy, the participant has reported significant reductions in pain, improved mobility, and the ability to climb stairs without support. Sessions are ongoing to support further recovery.

 

Findings: Continued improvement in pain, mobility, and daily function

Safety: No adverse side effects reported

Limitations: Single-case observation; follow-up MRI pending

 

This exploratory case suggests potential non-invasive support for degenerative joint conditions where surgical intervention is commonly recommended.

 

 

Age-Related Macular Degeneration (Ongoing Single-Case Observation)

This case involves age-related macular degeneration (AMD) with progressive central vision loss. The 88-year-old participant presented with severely reduced visual acuity, historically limited to approximately 40–50% in the left eye and 5–10% in the right eye, with the right eye able to detect only light sources. Previous clinical management included anti-inflammatory and anti-VEGF injections, as well as intraocular lens optimization, each reaching usage limits without meaningful improvement. No conventional therapeutic options remained available.

 

During ongoing therapy, the participant has reported notable improvements in the functional vision of the right eye, including clearer perception of objects previously indistinguishable. Follow-up assessment using Optical Coherence Tomography (OCT) imaging is planned to evaluate retinal changes.

 

Findings: Subjective improvement in central visual perception, especially in the right eye

Safety: No adverse side effects reported

Limitations: Single-case observation; follow-up OCT pending

 

This exploratory case suggests potential non-invasive support for visual function in age-related macular degeneration, particularly in situations where pharmacologic and procedural options are exhausted.

 

Glaucoma (Ongoing Single-Case Observation)

This case involves advanced glaucoma with approximately 90% vision loss in the left eye. The participant has undergone multiple ophthalmologic procedures, and no further conventional treatment options remain to address the existing vision loss. DBSS-based therapy has recently been initiated as a non-invasive exploratory approach. The planned protocol applies a stepwise SVZ-targeted neuromodulation strategy, with sequential focus on the optic nerve head and optic nerve, retinal ganglion cell layer (GCL), nerve fiber layer (NFL), and additional retinal structures.

 

Findings: Ongoing; early subjective signs of increased activity in the left eye reported

Safety: No adverse effects observed to date; monitoring ongoing

Limitations: Single-case observation; early-stage intervention

 

This exploratory case is being monitored to evaluate safety, feasibility, and potential biological activity in advanced glaucoma.

 

Nocturnal Epilepsy (Ongoing Single-Case Observation)

This case involves nocturnal seizure activity occurring exclusively during sleep, historically averaging 20–40 episodes per night with no daytime events. During therapy, nightly seizure frequency has been reduced to a maximum of two. The current objective is to reach zero episodes while maintaining medication, followed by gradual medication tapering to assess long-term stability.

 

Findings: Significant reduction of nocturnal seizures from 20–40 to ≤2 per night

Safety: No adverse side effects reported

Limitations: Single-case observation; long-term medication withdrawal pending

 

This exploratory case suggests potential support for nocturnal seizure control in individuals who remain symptomatic despite conventional management.

 

 

Upcoming Research

Our research is continuously expanding, with additional studies nearing completion. Additional DBSS studies and reports are in development across several neurological, psychological, and physiological applications.

 

  • DBSS Research for Schizophrenia
  • DBSS Research for Restless Legs Syndrome (RLS)
  • DBSS Research for Migraine
  • DBSS Research for Fibromyalgia
  • DBSS Research for Stress

 

 

Future Directions and Exploratory Research

Current initiatives include:

 

  • Stage 2 Studies for Resistant Hypertension: Early results indicate potential support for managing blood pressure in cases unresponsive to medication. Further validation is in progress.

 

  • Exploratory Research on Brain-Immune Interaction: Investigations are underway to assess how sound-based neuromodulation may influence immune regulation, with the goal of identifying new pathways for treating immune-related disorders.

 

Collaboration and Licensing Opportunities

Vital Tones is actively seeking partnerships to expand the research, validation, and clinical applications of DBSS. We invite inquiries from:

  • Research Labs: Collaborate with us to investigate DBSS, conduct pilot studies, evaluate proposed neural targets, and contribute independent findings.
  • Clinical Partners: Clinics and healthcare providers interested in implementing DBSS for patient treatment are encouraged to reach out to explore collaborative possibilities.
  • Investors: We are seeking investment to scale DBSS technology and accelerate its adoption. Our accumulated research, practical development history, and expanding applications position DBSS as a promising platform for further development in neuromodulation and related fields.

 

For serious inquiries, we offer additional details on licensing terms and customizable collaboration options. Please contact us directly at [email protected] to learn more.

 

Join Our Mission

Vital Tones is seeking passionate individuals with expertise in neuroscience, clinical research, business development, and other related fields to join our groundbreaking work with DBSS technology. If you’re inspired by the potential of non-invasive brain stimulation and want to contribute to a pioneering endeavor in neuroscience, we encourage you to connect with us.

 

 

 

 

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